As of Box Drive v2.43, Box Drive now integrates with Box Sign. However, this integration does not support Part 11 compliant signatures. Since Part 11 compliance is enabled and enforced for all users in our organization, this presents a risk, as users could inadvertently bypass this requirement when using the integrated Box Sign feature via Box Drive.

From Box Support "...when a user clicks on the "Send to Box Sign" option from Box Drive, Box Drive sends a "Signature Request" to Box Sign API. When the request is successfully processed, Box Sign API replies with “prepare_url” in response. We then open that url in the default browser. In further conversation with our Sign Engineers, they have let us know support for Part 11 is not compliant via the Box Sign APIs, as outlined in 21 CFR Part 11 Compliance Support. "